The research mainly focuses on:

• Production, purification, characterization, and optimization of industrially and medically important exopolysaccharides by extremophiles
• Chemical modifications of exopolysaccharides and their characterization
• Levan-based bioactive films and surfaces
• Formation of nanostructured thin films by Matrix Assisted Pulsed Laser Evaporation (MAPLE) and gradient organic thin films by Combinatorial Matrix-Assisted Pulsed Laser Evaporation (C-MAPLE)
• Anti-cancer, immunostimulating, and anticoagulation activities of exopolysaccharides
• Biocompatibility studies of biomaterials and biofilms
• Investigate new materials synthesis, formulation to designate their therapeutic efficacy.

Projects are financially supported by:

• TUBİTAK (The Scientific and Technological Research Council of Turkey) through projects MAG-111M232, MAG-112M330, TBAG-111T016, MAG-108M193, MAG-105M335, MAG 114M239.
• Marmara University Research Fund through projects FEN-C-DRP-030912-0306, FEN-C-YLP-210311-0057, FEN-D-110412-0103
• EU-COST Action TD0906 : Biological Adhesives: From Biology to Biomimetics 

Research topics are:

• Development of low-cost microbial production processes for levan polysaccharide
• Levan-based biomaterials for tissue engineering applications
• Production, purification, and characterization of exopolysaccharides by halophilic (Halomonas smyrnensis AAD6^T) and thermophilic  (Brevibacillus thremoruber) microorganisms
• Investigation of biological activities of levan-based polymers in vitro and in silico (in collaboration with Prof Bucak / Yeditepe University and Prof Ozisik / Rensselaer Polytechnic Institute) 
• Development of nanostructured functional biosurfaces by laser direct writing technologies (in collaboration with Prof Mihailescu / National Institute for Lasers, Plasma and Radiation Physics, Romania) 
• EPS production by archaea (in collaboration with Prof Nicolaus and Prof Romano / Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Italy)
• Levan-based drug carrier systems (in collaboration with Prof Eroglu / Marmara University, Chemical Engineering Department)
• Designing novel nanomaterials to develop drug delivery systems, multifunctional nanoparticles, polymeric blend films and coatings.
• production of nanoparticles and their material characterizations through AFM, SEM, NMR, FTIR, GPC-LS, TGA and DSC

Completed researches are:

• Exopolysaccharide production by Brevibacillus thermoruber (in collaboration with Prof Kambourova / Bulgaria Academy of Sciences)
• High level production of levan polysaccharide by Halomonas smyrnensis AAD6^T (in collaboration with Prof Nicolaus / Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Italy)
• Potential use of levan as a bioflocculating agent (in collaboration with Prof Yenigun / Boğaziçi University, Institute of Environmental Sciences and Prof Yukselen / Marmara University, Department of Environmental Engineering)
• Suitability of levan for drug nanocarrier systems (in collaboration with Prof Akbuga / Marmara University, Department of Pharmaceutical Biotechnology)
• Antioxidant potential of levan in high glucose condition in the pancreatic β-cells (in collaboration with Prof Khaper / Northern Ontario School of Medicine, Lakehead University, Canada)
• Development of nanostructured functional biosurfaces by laser direct writing technologies (in collaboration with Prof Mihailescu / National Institute for Lasers, Plasma and Radiation Physics, Romania) 

Presented Studies:

 

1.Erginer M., Cansever Mutlu E., Eroglu M.S., Toksoy Öner E. Levan-based Adhesive Surfaces for Biomedical Applications. in 2^nd 
Internatinal Conferance on Biological Adhesives Biology to Biomimetics. 2014. Istanbul. (Oral Presentation) 2014 


 

2. Cansever Mutlu E., Bahadori F., Kazak Sarilmiser H., Toksoy Oner E., Eroglu M.S. Levan Coated Nano Particles For Tumor 
Targeting Delivery. in 2nd International Conferance On Biological & Biomimetic Adhesives. Istanbul (Poster Presentation) 2014 


 

3. Eroglu M. S., Mutlu E., Sennaroglu Bostan M., Toksoy Oner E. The Effect of Levan on the Morphological and Mechanical Properties of Chitosan Polyethyleneoxide Blend Films. 9th World Biomaterials Congress. Chengdu, 3 China (Poster Presentation) 2012

 

4. Sima F. Cansever Mutlu E., Eroglu M. S., Sima L.E. , Serban N. , Ristoscu C. , Petrescu S.M. Toksoy Oner E., Mihailescu I. Levan thin films by MAPLE. 9th World Biomaterials Congress. Chengdu, China (Poster Presentation) 2012 


 

5. 
Toksoy Oner E., Mutlu E., (2010) A Promising Bioglue from An Extremophile. COST TD0906 Workshop, Biological 
Adhesives: from biology to biomimetics. Vien, Austria (Oral Presentation) 2010 


 

6. Kazak H, Gökmen B, Ates O, Güney D B ,Mutlu E, Gürleyendag B, Kucukasik F, Toksoy Öner E,. A Promising 
Biopolymer from Halophilic Bacteria. International Meeting The 5th Congress for Bioengineering. Izmir, Turkey 
(Oral Presentation) 2010 


 

7. Cansever E and Turker AU. In vitro culture and biological activity of Solanum dulcamara L., a medicinal plant 
. 55th Congress of the Society of Medicial Plant Research, Graz, Austria. Planta Medica 73(9): 881-881 P182. 
(Meeting abstract) 2007 


 

8.  Cansever E ve Turker AU (Solanum dulcamara L. bitkisinin in vitro kültür yöntemi ile çoğaltımı. Biyoteknoloji Yüzyılı ve Türkiye Kongresi Özet Kitapçıgı, Sabancı University –Istanbul, Turkey sayfa 29 (Oral Presentation) 2006